Zoloft Drug Uses

Zoloft is a prescription medicine used to treat depression, panic disorder, obsessive-compulsive disorder (also called OCD) and posttraumatic stress disorder (also called PTSD) in adults. Zoloft is also used to treat OCD in children (ages 6-12) and adolescents (ages 12-17).

How Taken

Zoloft comes as a tablet to take it orally. It is usually taken once daily and may be taken with or without food. Take Zoloft exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Zoloft even if you feel well. Do not stop taking Zoloft without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Zoloft Warnings/Precautions

Before taking Zoloft, tell your doctor if you have liver disease; kidney disease; suffer from seizures; or suffer from mania or have suicidal thoughts. You may not be able to take Zoloft, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Zoloft is in the FDA pregnancy category C. This means that it is unknown whether it will be harmful to an unborn baby. Do not take Zoloft without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zoloft passes into breast milk. Do not take Zoloft without first talking to your doctor if you are breast-feeding a baby.

Zoloft Missed Dose

If you take Zoloft once a day in the morning, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. If you take Zoloft once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not take a double dose to make up for a missed one.

Zoloft Possible Side Effects

If you experience any of the following serious side effects, stop taking Zoloft and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); an irregular heartbeat or pulse; low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); or chills or fever. If you experience any of the following less serious side effects, continue taking Zoloft and talk to your doctor: headache; tremor, nervousness, or anxiety; nausea, diarrhea, dry mouth, or changes in appetite or weight; sleepiness or insomnia; or decreased sex drive, impotence, or difficulty having an orgasm. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Zoloft Storage

Store at 25°C (77°F); excursions permitted to 15° - 30°C (59° - 86°F).

Zoloft Overdose

Seek emergency medical attention. Symptoms of a Zoloft overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Zoloft may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking Zoloft.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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A team of researchers from the University of Texas at Austin, led by Kereshmeh Taravosh-Lahn, conducted an animal study in juvenile and adult golden hamsters. The researchers split the hamsters into three groups: adult hamsters receiving either high or low doses of fluoxetine (Prozac), adolescent hamsters receiving high or low doses of fluoxetine, and hamsters receiving placebo. A high dose consisted of 20 mg per kilo of body weight, while a low dose was 10 mg per kilo.
After administering the drugs, the researchers placed a smaller, same-sex hamster into the cage of each experimental animal, and filmed any fights or displays of aggressive behavior. The researchers found that the adolescent hamsters on a low dose of Prozac were far more aggressive than those on high doses of the drug.
The high-dose hamsters initiated 65 percent fewer attacks than the placebo group, while the low-dose hamsters initiated 40 percent more fights. Adult hamsters on both high and low doses of Prozac initiated fewer fights than the placebo group, the researchers found.
Taravosh-Lahn said the difference in aggression between the high- and low-dose hamsters could be because fluoxetine binds serotonin -- a mood-altering brain chemical -- to different receptors in the brain, depending on the dose. The researchers speculate that low doses of the drug may bind to aggression-inducing receptors, while higher doses more readily bind to aggression-inhibiting receptors. Mature animals also have fewer aggression-inducing inhibitors for the drugs to bind to, compared to adolescent animals.
"We underestimate the difference between the juvenile brain and the adult brain," said Taravosh-Lahn. "It seems there needs to be more research on the effects of antidepressants on kids."
Earlier studies have linked use of antidepressant drugs -- specifically SSRIs (selective serotonin reuptake inhibitors) -- to violent and aggressive behavior in children. A high-profile case involving Pzifer's Zoloft SSRI is that of Christopher Pittman, who at the age of 12 shot and killed his grandparents, then set their house on fire. Pittman's attorneys argued that the Zoloft he was taking at the time of the killings caused him to become violent, but a jury disagreed and sentenced him to 30 years in prison in February 2005.
In 2004, the U.S. Food and Drug Administration required that all antidepressants carry the agency's most serious "black box" warning, which cautions that the drugs can cause suicidal thoughts or abnormal behaviors in teenage users.

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