Synalar Cream Drug Uses

Synalar Cream is used to reduce itching, redness, and swelling associated with many skin conditions.

How Taken

Apply a small amount of medicine to the affected area. Gently rub the medicine in until it is evenly distributed. Wash your hands after applying this medicine, unless your hands are part of treated area. Do not bandage or wrap the affected area unless directed otherwise by your doctor.

Synalar Cream Warnings/Precautions

If your condition shows no signs of improvement or becomes worse within a few days, check with your doctor. Avoid contact with the eyes. Do not use Synalar Cream longer than the time prescribed. Tell your doctor if you are breast-feeding before taking this medicine.

Synalar Cream Missed Dose

If you miss a dose, apply it as soon as you remember. If it is near the time of the next application, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Synalar Cream Possible Side Effects

Some of the side effects you may experience include: skin thinning and discoloration, itching, burning, redness, or swelling not present before using this medicine.

Synalar Cream Storage

Store Synalar Cream at room temperature, away from heat and light. Keep out of the reach of children.

Synalar Cream Overdose

Synalar Cream may be harmful if swallowed. Seek emergency medical attention if an overdose is suspected.

More Information

Do not use this medicine for purposes other than those for which it was prescribed. Do not share Synalar Cream with others.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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A: Your order is dispatched through our order system to a licensed physician who will review the information you have submitted and approve or decline your request of Synalar Cream. When your order is approved, the physician will then write your prescription and our ordering system will ensure that it is sent to the pharmacy where it will be filled and shipped.


Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

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