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Pharmacy NewsFriday 21 November 2008
Combination Pain Treatment Now Available in Canada
TRAMACET* Combines Two Pain Treatments Each Used Worldwide For More Than 25 Years
Toronto, Ontario (July 25, 2005) – Health Canada has approved TRAMACET* (tramadol hydrochloride / acetaminophen) for the short-term (five days or less) management of acute pain. TRAMACET combines tramadol, a widely prescribed pain medication outside Canada, with acetaminophen, a commonly used nonprescription pain treatment.
"TRAMACET bridges the treatment gap between over-the-counter pain medications and more potent prescription pain medications, giving Canadians who suffer from acute pain another treatment option," says Dr. Allan Gordon, Neurologist and Director of the Wasser Pain Management Centre at Mount Sinai Hospital in Toronto. "The availability of other treatment options is important to physicians and patients, especially in today's changing pain treatment environment."
Studies have demonstrated that TRAMACET provides better pain relief than either tramadol or acetaminophen alone, faster onset of action than tramadol and longer duration of relief than acetaminophen. In clinical trials, TRAMACET was shown to be well tolerated with low rates of constipation, vomiting and discontinuation.
"Tramadol and acetaminophen have been used separately worldwide for pain relief for over 25 and 50 years respectively," says Dr. André Bélanger, Member of the Geriatric Service at Centre hospitalier Chauveau, Québec. "Tramadol has been available for decades in many other countries and has over 400 million days of patient experience worldwide."
Clinical Trial Information
In a randomized, double-blind, placebo-controlled trial of orthopaedic and abdominal surgery patients published in The American Journal of Surgery, TRAMACET demonstrated similar efficacy and better tolerability than a leading codeine combination treatment.
In the study, the rate of constipation for patients treated with TRAMACET was less than half the rate experienced by patients treated with the codeine combination (4.1 per cent vs. 10.1 per cent). Also, TRAMACET patients experienced less vomiting (9.2 per cent vs. 14.7 per cent) and discontinuation due to adverse events (8.2 per cent vs. 10.1 per cent).
In a study of osteoarthritic patients with flare-ups published in The Journal of The American Geriatrics Society, the addition of TRAMACET to non-selective or COX-2 selective NSAID therapy provided significant improvement in pain relief and reduction of pain intensity compared with placebo.
TRAMACET has also been shown to be effective at providing pain relief following oral surgical procedures.
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